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Updated: Apr 18, 2026

Chemical Modification of the Tryptophan Residue in a Recombinant Ca2+-ATPase N-domain for Studying Tryptophan-ANS FRET
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Chemical Modification of the Tryptophan Residue in a Recombinant Ca2+-ATPase N-domain for Studying Tryptophan-ANS FRET

Published on: October 9, 2021

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タンパク質の構造. トリプトファンに富んだTSPOタンパク質の構造と活性

Youzhong Guo1, Ravi C Kalathur2, Qun Liu3

  • 1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.

Science (New York, N.Y.)
|January 31, 2015
PubMed
まとめ

トランスロケータータンパク質 (TSPOs) はステロイドとポルフィリンと結合し,疾患のバイオマーカーとして作用します. この研究では,プロトポルフィリンIX (PpIX) の分解におけるそれらの結晶構造と触媒的活性が明らかになり,酸化ストレスからの保護における役割を示唆しています.

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