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A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

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生まれながらの免疫アダプタータンパク質MAVS,STING,TRIFのリン酸化により,IRF3の活性化が誘発される

Siqi Liu1, Xin Cai1, Jiaxi Wu1

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

Science (New York, N.Y.)
|February 1, 2015
PubMed
まとめ

この研究では,アダプタータンパク質MAVSとSTINGのリン酸化が,インターフェロン調節因子3 (IRF3) の募集と活性化において,タイプIインターフェロン (IFN) の抗ウイルス反応の開始において極めて重要であることが明らかになりました.

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