関連する実験動画
Updated: Oct 9, 2026
08:05
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
トリコフィトンの喘息:気管と上部呼吸道が皮膚植物抗原に対する感受性を持つ
1Department of Internal Medicine, University of Virginia, Charlottesville.
Lancet (London, England)
|April 22, 1989
まとめ
喘息や皮膚感染症を患っている大人は,Trichophyton.のような真菌に対して過敏症になることがあります. この真菌への曝露は,呼吸道炎症を引き起こし,喘息と慢性鼻炎の症状を引き起こす可能性があります.
科学分野:
- アレルギーと免疫学
- 肺内科 肺内科 肺内科
- 皮膚科 皮膚科について
背景:
- 恒常性喘息は,しばしばアレルギーのトリガーと関連しています.
- 慢性的な皮膚感染症は,時には免疫系の問題を暗示することがあります.
研究 の 目的:
- 喘息と慢性皮膚感染症の患者における真菌過敏症と呼吸器系症状の関連性を調査する.
- これらの患者でTrichophyton種が呼吸道炎症を誘発するかどうかを判断する.
主な方法:
- 12人の長年の喘息と慢性皮膚感染症の成人の患者を評価した.
- Trichophyton tonsuransの抽出物で支障管の挑発テストを実施しました.
- ダブルブラインドで,プラセボ対照で,皮膚素抗原を用いた鼻のチャレンジを実施しました.
主要な成果:
- Trichophyton spp.に対する即時の過敏症. すべての患者で確認されました.
- 支柱管の挑発は,10人の患者で即時の反応を示した.
- 鼻のチャレンジにより,8人の患者で真菌抗原に対する上部呼吸道感受性が確認されました.
- 患者は,喘息とともに,持続的なエオシノフィリアと慢性的な鼻炎を示した.
結論:
- 菌類抗原の吸収は,IgE抗体生成と呼吸道敏感化につながる可能性があります.
- トリコフィトンに対する真菌過敏症は,症状性喘息および慢性鼻炎に寄与する可能性があります.
- 発見は,内在的な喘息のプレゼンテーションにおける皮膚細胞の潜在的な役割を示唆しています.
さらに関連する動画
06:34A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
10:39Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
Published on: April 16, 2019
関連する概念動画
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:29Asthma-I: Introduction
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
01:26Asthma-II: Pathophysiology and Classification
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
01:29Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
01:13Asthma III: Clinical Manifestations
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...