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Updated: Apr 17, 2026

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
07:10

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay

Published on: September 14, 2014

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アフィニティ成熟期における選択力を操作して,交叉反応性HIV抗体を生成する

Shenshen Wang1, Jordi Mata-Fink2, Barry Kriegsman3

  • 1Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139.

Cell
|February 10, 2015
PubMed
まとめ

交叉反応性抗体の生成は,変異性病原体との闘いにおいて極めて重要です. コクテルとは異なり,抗原変異体による連続免疫は,シリコンモデルとマウス実験によって示されたように,これらの抗体を誘発するために好ましい.

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Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood13:14

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood

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Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding10:50

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding

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