献血後の経口鉄補給:ランダム化臨床試験
Joseph E Kiss1, Donald Brambilla2, Simone A Glynn3
1Institute for Transfusion Medicine, Pittsburgh, Pennsylvania.
JAMA
|February 11, 2015
まとめ
経口鉄補給は,献血者におけるヘモグロビンと鉄の貯蔵量の回復を著しく加速する. この介入は,ドナー,特にフェリチン量が低いドナーが,献血後に鉄のレベルを早く補うのを助けます.
科学分野:
- 血液学 ヘマトロジ
- 栄養科学とは,栄養科学である.
- 輸血医学とは
背景:
- 米国では8週間ごとに献血が許可されています.
- ヘモグロビンの回復が12.5g/dLに達することは,しばしば献血後の遅延です.
- 回復が遅れたため,一部の献血者は貧血を発症する.
研究 の 目的:
- ヘモグロビン回復時間に対する経口鉄の影響を評価するために.
- 献血者における鉄貯蔵の補充を評価するために.
- 鉄欠乏症 (低フェリチン) と鉄補充 (高フェリチン) のドナーにおける効果を比較する.
主な方法:
- 4つの米国の血液センターでランダム化され,盲目化されていない臨床試験.
- 215人の参加者 (18歳から79歳) がフェリチン,性別,年齢によって層分かれました.
- 処置:献血後の24週間にわたり,毎日鉄性グルコナート (37.5mgの元素鉄) またはプラセボを投与する.
主要な成果:
- 鉄補給は,低フェリチン量 (32日対158日) と高フェリチン量 (31日対78日) の両群でヘモグロビン回復時間を80%短縮しました.
- 発症時のフェリチンの平均回復は,鉄分投与で21日 (低フェリチン) と107日 (高フェリチン) でした.
- 鉄がなければ,参加者の67%が168日以内に鉄の貯蔵を回収できませんでした.
結論:
- 低用量の鉄補給は,献血後のヘモグロビン回復を加速する.
- 鉄のサプリメントは,献血者の鉄の貯蔵量を効果的に回復します.
- この戦略は,鉄欠乏体と鉄補充体の両方のドナーに利益をもたらします.
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