パーキンソン病患者の臨床進行に対するクレアチン・モノヒドラートの効果:ランダム化臨床試験
, Karl Kieburtz1, Barbara C Tilley2
1University of Rochester, Rochester, New York.
JAMA
|February 11, 2015
まとめ
クレアチンモノヒドレートは,早期のパーキンソン病患者の臨床衰退を5年以上にわたって遅らせることはありませんでした. この研究は,パーキンソン病の治療のためにクレアチンの使用を支持していません.
科学分野:
- 神経学 神経学とは
- 神経変性疾患 神経変性疾患とは
- クリニック・トライアル 臨床試験
背景:
- パーキンソン病 (PD) は進行を遅らせる治療法がないため,世界的な健康負担を大きくしています.
- 国立神経疾患・脳卒中研究所は,新しい治療法を見つけるため,パーキンソン病の探索試験プログラムを設立しました.
研究 の 目的:
- パーキンソン病患者の長期的な臨床衰退を遅らせるために,クレアチンモノヒドレートがプラセボよりも有効かどうかを評価する.
主な方法:
- 多センター,ダブルブラインド,プラセボ対照試験では,1741人のパーキンソン病の初期段階の患者をランダムにプラセボまたはクレアチン (10g/d) に割り当てました.
- 参加者は少なくとも5年間追跡調査され,臨床状態の測定法, Modified Rankin Scale (修正ランキンスケール) や日常生活の活動などを用いて評価された.
主要な成果:
- 955人の参加者の中間分析 (フォローアップの平均期間は4年) 後に無益性のために試験は早期に終了されました.
- クレアチン群とプラセボ群 (P=.45) の間で,臨床的衰退の有意な違いは観察されなかった.
- 副作用は,グループによって有意に異なるものではありませんでした.
結論:
- 長期にわたるクレアチン・モノヒドレート治療は,プラセボと比較して,早期に治療されたパーキンソン病患者の臨床結果を改善しませんでした.
- これらの発見は,パーキンソン病の管理のためにクレアチンモノヒドレートの使用を支持しません.
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