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Updated: Apr 17, 2026

Purification of Hsp104, a Protein Disaggregase
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進化的に保存されたTyr169は,プリオンタンパク質のβ2-α2ループを安定させる

Danzhi Huang1, Amedeo Caflisch

  • 1Department of Biochemistry University of Zürich , Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

Journal of the American Chemical Society
|February 12, 2015
PubMed
まとめ

プリオンタンパク質のβ2-α2ループ構造は,その変換の鍵です. 特定の変異 (Y169G) は,このループ移行のエネルギーバリアを下げ,プリオン集積に影響を与えます.

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