関連する実験動画
Updated: Aug 3, 2026

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A Method For Production of Recombinant mCD1d Protein in Insect Cells.
Published on: December 10, 2007
CD2抗原は,ヒトTリンパ球の表面にあるT細胞抗原受容体CD3抗原複合体と結合する
M H Brown1, D A Cantrell, G Brattsand
1Cell Surface Biochemistry, Imperial Cancer Research Fund, Lincoln's Inns Fields, London, UK.
Nature
|June 15, 1989
まとめ
Tリンパ球は,T細胞受容体CD3 (Ti-CD3) とCD2分子を活性化するために利用する. この研究は,CD2分子がTi-CD3複合体と物理的に結合することを実証し,T細胞の信号伝達における機能的なリンクを示唆しています.
科学分野:
- 免疫学 免疫学とは
- 細胞生物学 細胞生物学
- 分子生物学は分子生物学である.
背景:
- Tリンパ球は,T細胞受容体CD3 (Ti-CD3) 複合体またはCD2分子を標的とした刺激によって活性化されます.
- CD2シグナル伝達の正確な役割と,Ti-CD3経路との関係については,現在調査中です.
- 以前の研究では,CD2媒介のT細胞活性化においてTi-CD3の必要性が示唆されている.
研究 の 目的:
- T細胞表面のTi-CD3複合体とCD2分子との潜在的な物理的関連性を調査する.
- CD2シグナル伝達がTi-CD3複合体と機能的に関連しているかどうかを判断する.
主な方法:
- デジトニンベースの溶解化手順を使用しました.
- 分子相互作用を評価するために共同降水技術を使用した.
- Tリンパ球の細胞表面構造を分析した.
主要な成果:
- 細胞表面のCD2分子の大部分 (40%) がTi-CD3複合体と特異的に共降することが示された.
- CD2とTi-CD3.3との間の物理的な関連性に対する直接的な証拠を提供した.
結論:
- この発見は,CD2およびTi-CD3複合体がT細胞表面に物理的に関連しているモデルを支持する.
- この物理的な相互作用が,T細胞活性化経路における観察された機能的相互依存の根底にある可能性が高い.
関連する概念動画
Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Diversity of Antigen Receptors
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Antigen Processing Pathways
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
MHC Class I: Presenting Endogenous...
T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
B Cell Activation and Differentiation
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

