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がん特異的なユビキチンリガゼによるAMPKの劣化

Carlos T Pineda1, Saumya Ramanathan1, Klementina Fon Tacer1

  • 1Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Cell
|February 14, 2015
PubMed
まとめ

癌細胞は,MAGE-A3/6-TRIM28.28を含む生殖系メカニズムをハイジャックすることによって,AMP活性化タンパク質キナーゼ (AMPK) を抑制する. これはAMPKα1の分解につながり,がんの成長を促進し,AMPKを標的とする薬に対する感受性を高めます.

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