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Updated: Apr 17, 2026

Author Spotlight: Imaging ATG9A, a Multi-Spanning Membrane Protein
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ATG14は,膜結合を促進し,オートファゴソームをエンドリゾソームに融合させます

Jiajie Diao1, Rong Liu2, Yueguang Rong3

  • 11] Department of Molecular and Cellular Physiology, Stanford University, Stanford, California 94305, USA [2] Department of Structural Biology, Stanford University, Stanford, California 94305, USA [3] Department of Photon Science, Stanford University, Stanford, California 94305, USA [4] Department of Neurology and Neurological Sciences, Stanford University, Stanford, California 94305, USA [5] Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA.

Nature
|February 18, 2015
PubMed
まとめ

ATG14タンパク質は,オートファギーにおいて,オートファゴソームとリソソームの間の膜融合を促進することによって極めて重要です. そのホモオリゴメリゼーションは,このプロセスに不可欠であり,様々なヒト疾患における貨物の劣化を保証します.

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