C型肝炎 (C型肝炎) について

Daniel P Webster¹, Paul Klenerman², Geoffrey M Dusheiko³

¹Department of Virology, Royal Free London NHS Foundation Trust, London, UK.

Lancet (London, England)

|February 18, 2015

まとめ

C型肝炎ウイルス (HCV) 感染症は,世界的な健康問題です. 新しい直接作用の抗ウイルス薬は,古いインターフェロン治療法を上回り,HCVに対する改善された,より短い経口治療を提供します.

科学分野:

肝臓病理学肝臓病理学
ウイルス学ウイルス学ウイルス学
感染症感染症は感染症です.

背景:

C型肝炎ウイルス (HCV) 感染症は,深刻な肝硬変や癌などの重篤な肝疾患につながる,世界的な健康負担を大きくします.
HCV/HIV共感染は,より悪い患者のアウトカムでより大きな課題を提示します.
インターフェロンとリバビリンによる現在の標準治療は,有効性が限られている (約50%の持続性ウイルス学的応答) であり,重大な副作用がある.

研究の目的:

HCVウイルス学に関する理解の進展をレビューする.
新しい直接作用抗ウイルス薬 (DAA) の開発と効果を強調する.
C型肝炎の治療状況の変化について議論する.

主な方法:

HCVウイルス学と治療の進歩に関する科学文献のレビュー.
新しい直接作用の抗ウイルス治療法の有効性と耐容性の分析.
インターフェロンベースの過去の治療とDAA療法の比較.

主要な成果:

HCV細胞培養における進歩は,ウイルスの複製を標的とした直接作用の抗ウイルス薬の開発を促しました.
DAAは,HCVに対する簡素化,短縮,および経口治療を可能にします.
新しい治療法では,インターフェロンとリバビリンと比較して,有効性が向上し,耐受性が向上しています.

結論:

直接作用の抗ウイルス薬は,C型肝炎ウイルス感染症の治療において大きな進歩を遂げています.
改善された治療法により,HCVの管理と治療の可能性が向上します.
医療への平等なアクセスを確保し,予防的なワクチンを開発するという課題は依然として残っています.

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