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Updated: Apr 17, 2026

Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay
08:40

Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay

Published on: May 2, 2019

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インスリン粒. インスリン分泌粒子は,臓のβ細胞の自を制御する

Alexander Goginashvili1, Zhirong Zhang1, Eric Erbs1

  • 1Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM, CNRS, Université de Strasbourg, 67404 Illkirch, France.

Science (New York, N.Y.)
|February 21, 2015
PubMed
まとめ

飢えた臓ベータ細胞はマクロオートファギーを抑制し,代わりにタンパク質キナーゼD (PKD) 経路を通じてインスリン粒子を分解する. このメカニズムは,栄養素の枯渇時にインスリン放出を低下させ,ベータ細胞を断食に適応させます.

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