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Updated: Apr 17, 2026

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
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キナーゼのダイナミクス. 古代のタンパク質キナーゼを用いて,現代のがん薬のメカニズムを解明する

C Wilson1, R V Agafonov1, M Hoemberger1

  • 1Howard Hughes Medical Institute and Department of Biochemistry, Brandeis University, Waltham, MA 02452, USA.

Science (New York, N.Y.)
|February 21, 2015
PubMed
まとめ

腫瘍遺伝子のSrcとAblの進化的再構築は,ガン薬のGleevecがどのようにして特異性を獲得したかを明らかにしています. この研究は,Gleevecの背後にある原子化メカニズムを詳細に説明しています.

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