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Updated: Apr 17, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease
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病気のネットワーク 病気のネットワーク 不完全なインタラクトームを通して,病気と病気の関係を明らかにする

Jörg Menche1, Amitabh Sharma2, Maksim Kitsak2

  • 1Center for Complex Networks Research and Department of Physics, Northeastern University, 110 Forsyth Street, 111 Dana Research Center, Boston, MA 02115, USA. Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Center for Network Science, Central European University, Nador u. 9, 1051 Budapest, Hungary.

Science (New York, N.Y.)
|February 21, 2015
PubMed
まとめ

人間のインタラクトームは,疾患モジュールをマップし,そのネットワークの位置が疾患間の関係を予測する方法を明らかにします. このアプローチは,共有されたプライマリ遺伝子がなくても,関連疾患の共有された分子基盤を特定します.

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