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Updated: Apr 17, 2026

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V(D) J再結合酵素RAG1-RAG2の結晶構造について

Min-Sung Kim1, Mikalai Lapkouski1, Wei Yang1

  • 1Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, Maryland 20892, USA.

Nature
|February 25, 2015
PubMed
まとめ

RAG1-RAG2複合体の構造は,そのY形を明らかにし,免疫系におけるV(D) J再結合に極めて重要です. この発見は,免疫不全患者の突然変異を説明し,DNAトランポザースとの進化的つながりを示唆しています.

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