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Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
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休眠状態からの脱出は,血液形成性幹細胞のDNA損傷による脱落を引き起こします

Dagmar Walter1, Amelie Lier1, Anja Geiselhart2

  • 1Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany.

Nature
|February 25, 2015
PubMed
まとめ

生理学的ストレスは,血液形成性幹細胞 (HSC) を活性化し,DNAの損傷を引き起こします. この損傷は,HSCの老化を加速し,特にファンコーニ貧血の個体において,骨髄不全につながる.

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