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N(6) -メチラデノシン依存RNA構造スイッチは,RNAとタンパク質の相互作用を調節する

Nian Liu1, Qing Dai1, Guanqun Zheng2

  • 1Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA.

Nature
|February 27, 2015
PubMed
まとめ

N(6) -メチラデノシン (m(6) A) 改変は"m(6) Aスイッチ"として作用し,RNAの構造を変化させ,RNAとタンパク質の相互作用を制御します. このメカニズムは,RNA結合モチーフへのRNA結合タンパク質のアクセスを影響することによって,遺伝子発現とRNA成熟を調節する.

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