人体内皮質に由来する酸化窒素が,外周動脈動脈のトーンに及ぼす影響
P Vallance1, J Collier, S Moncada
1Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London.
Lancet (London, England)
|October 28, 1989
まとめ
酸化窒素 (NO) は,血流の制御に不可欠です. NGモノメチル-L-アルギニン (L-NMMA) とのNO合成を阻害すると,血流が低下し,アセチルコリンに対する反応が低下し,血管の健康におけるNOの役割が強調されました.
科学分野:
- 心血管生理学 心血管の生理学
- 内皮機能の機能について
- 酸化窒素の生物学について
背景:
- 内皮に由来する酸化窒素 (NO) は,血管調節に重要な役割を果たします.
- 基礎および刺激された血流に対するNOの貢献を理解することは,心臓血管の健康に不可欠です.
- 機能不全のNO生成は,様々な血管疾患に関与しています.
研究 の 目的:
- 人間の前腕の血流の制御における内皮由来のNOの役割を調査する.
- 基礎およびアセチルコリン刺激による血管拡張におけるNOの関与を決定する.
- 血管の反応性に対するNO抑制の影響を評価する.
主な方法:
- 特定のNO合成阻害剤であるNGモノメチル-L-アルギニン (L-NMMA) を,健康なボランティアの腕動脈に注入する.
- 前腕の血流の測定. 前腕の血流の測定. 前腕の血流の測定. 前腕の血流の測定. 前腕の血流の測定. 前腕の血流の測定.
- 挿入されたアセチルコリンとグリセリル三酸塩に対する血管反応の評価.
主要な成果:
- L-NMMAの注入は,基礎前腕の血流の有意な50%の減少をもたらしました.
- L-NMMAは,アセチルコリンによって誘発された血管拡張を弱めた.
- グリセリル三酸塩に対する膨張反応は,L-NMMAの影響を受けなかった.
結論:
- 内皮から派生するNOは,ヒトの基礎および刺激された地域血流の調節に有意に寄与する.
- NOの生産が低下した状態は,多くの疾患状態で観察された血管反応の異常の原因である可能性があります.
- NO経路をターゲットにすることは,血管機能不全の治療戦略かもしれません.
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