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Updated: Apr 16, 2026

Method for Efficient Refolding and Purification of Chemoreceptor Ligand Binding Domain
14:25

Method for Efficient Refolding and Purification of Chemoreceptor Ligand Binding Domain

Published on: December 12, 2017

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シトカイン受容体のシグナリングを調節し,代用リガンドで二次体幾何学を再方向化します

Ignacio Moraga1, Gerlinde Wernig2, Stephan Wilmes3

  • 1Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305-5345, USA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305-5345, USA.

Cell
|March 3, 2015
PubMed
まとめ

研究者らは,受容体二重体構造の変化が細胞シグナル伝達にどのように影響するか調査した. 彼らは,エンジニアリングされたダイアボディが受容体活動を制御することができ,がんを誘発する突然変異に対抗するための新しい戦略を提供することを発見しました.

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