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Updated: Apr 16, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
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チアゾリルペプチド天然製品の化学酵素合成で,酵素触媒化されたフォーマル [4 + 2] サイクロアディションが含まれています

Walter J Wever1, Jonathan W Bogart1, Joshua A Baccile2

  • 1†Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

Journal of the American Chemical Society
|March 6, 2015
PubMed
まとめ

研究者らは,チオシリン抗生物質のバイオシンセシスの最終段階を触媒する酵素であるTclMを特定した. これは,デヒドロアラニン間のユニークな [4+2] サイクロアディション反応を含み,シアゾリルペプチド経路を完了します.

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