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Updated: Apr 16, 2026

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
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A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

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構造生物学 構造生物学について ケモカイン認識とウイルスGタンパク質結合受容体の活性化のための構造的基礎

John S Burg1, Jessica R Ingram2, A J Venkatakrishnan3

  • 1Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Science (New York, N.Y.)
|March 7, 2015
PubMed
まとめ

研究者は,ヒトのケモカインに結合したウイルスケモカイン受容体 (GPCR) の構造を視覚化しました. これは,ウイルスのGPCRが外部信号なしでどのように活性化し続け,免疫回避戦略に影響を与えるかを明らかにします.

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