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ペントラキシン3は,P-セレクチン/マトリックスメタロプロテインアゼ-1経路を通じて,血管内皮機能障害を誘発する

Albino Carrizzo1, Paola Lenzi1, Claudio Procaccini1

  • 1From IRCCS Neuromed, Pozzilli, Italy (A.C., A.D., F.B., M.A., M.M., F.F., C.V.); University of Pisa, Department of Human Morphology and Applied Biology, Italy (P.L., F.F.); Laboratory of Immunology, Institute of Experimental Endocrinology and Oncology, National Research Council of Italy (IEOS-CNR), c/o Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Napoli, Italy; (C.P., V.G.); University of Salerno, Department of Pharmaceutical Sciences, Fisciano (Salerno), Italy (G.A.); University of Salerno, Medicine and Surgery, Baronissi (Salerno), Italy (G.A., P.R., A.A.P., G.M., C.V.); Hypertension Research Center and Department of Advanced Biomedical Sciences (D.G.C., B.T.) and Department of Translational Medical Sciences (R.I.), University of Naples "Federico II", Napoli, Italy; University of Pavia, Department of Industrial and Information Engineering, Italy (A. Malovini); Department of Science and Technology, University of Sannio, Benevento, Italy (L.F.); Pathology Unit, "Istituto Nazionale Tumori, IRCCS, Fondazione Pascale," Naples, Italy (V.G.); and IRCCS Multimedica, Milan, Italy (A.A.P., G.M.).

Circulation
|March 10, 2015
PubMed
まとめ

ペントラキシン3 (PTX3) は,酸化窒素の信号伝達を損なうことで,血管機能障害と高血圧を直接引き起こします. PTX3,P-セレクチン,およびマトリックスメタルプロテインアゼ-1の上昇は,高血圧の血管問題を予測する可能性があります.

キーワード:
生物学的マーカーエンソテリウム (endothelium) とは高血圧,高血圧を患っている.酸化窒素は窒素酸化物である.

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