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関連する概念動画

Knee Joint01:23

Knee Joint

3.8K
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
3.8K
Ankle Joint01:10

Ankle Joint

3.8K
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
3.8K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.9K
Structural Joints: Synovial Joints01:16

Structural Joints: Synovial Joints

9.9K
Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
9.9K
Functional Classification of Joints01:09

Functional Classification of Joints

9.2K
Functional Classification of Joints
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses  or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
9.2K
Bone Disorders01:29

Bone Disorders

8.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.7K

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Updated: Apr 16, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
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Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

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骨格関節炎 (Osteoarthritis) とは,骨格関節炎 (Osteoarthritis) とは,骨格関節炎 (Osteoarthritis) とは,骨格関節炎 (Osteoarthritis) とは,

S Glyn-Jones1, A J R Palmer1, R Agricola2

  • 1Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Lancet (London, England)
|March 10, 2015
PubMed
まとめ
この要約は機械生成です。

骨格関節炎 (OA) は,広範な痛みと障害を引き起こす. 早期診断と関節保全治療は不可欠ですが,早期OAとその進行を検出する現在の方法は依然として限られています.

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Synovial Fluid Analysis to Identify Osteoarthritis
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The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse
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関連する実験動画

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Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
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Synovial Fluid Analysis to Identify Osteoarthritis
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The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse
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科学分野:

  • レウマトロジーと整形外科
  • 運動器系疾患の流行病学

背景:

  • 骨格関節炎 (OA) は,世界的な痛み,障害,経済的負担の主要な原因です.
  • その複雑な流行病学には,関節によって異なる遺伝的,生物学的,および生体力学的要因が含まれています.
  • 現在の治療法は,末期疾患 (関節置換) に焦点を当て,機能的な結果と義肢の長寿を制限しています.

研究 の 目的:

  • 骨格関節炎の予防と早期治療への移行に取り組む.
  • 従来のイメージングの限界による早期OAの診断における課題を強調する.
  • 早期OAに対する新しい診断と成果測定の可能性を調査する.

主な方法:

  • 骨関節炎の流行病学と危険因子に関する現在の理解のレビュー.
  • 病気の早期発見のための従来のイメージングの限界の評価.
  • OA診断のためのイメージングと生化学マーカーの新興進歩の評価.
  • ライフスタイル,医薬品,外科的アプローチを含む,開発における共同保存介入の概要.

主要な成果:

  • 従来のイメージングは,高度な関節炎のみを検出し,痛みは必ずしも構造的損傷と相関するものではありません.
  • 画像と生化学マーカーの進歩は,早期診断と治療効果のモニタリングに希望を示しています.
  • いくつかの関節保存介入が調査されているが,疾患の進行を止めたり遅らせたりする能力を実証しているものはほとんどない.

結論:

  • 初期段階の骨格関節炎の診断と管理のための改善された方法が不可欠です.
  • 新興技術は,早期発見とより良い結果評価の可能性を秘めています.
  • OAの進行を遅らせるための効果的な関節保存戦略を検証し,実施するためにさらなる研究が必要です.