家族性高コレステロール血症と2型糖尿病の罹患率との関連
Joost Besseling1, John J P Kastelein1, Joep C Defesche2
1Department of Vascular Medicine, Academic Medical Centre, Amsterdam, the Netherlands.
JAMA
|March 11, 2015
まとめ
家族性高コレステロール血症の個人は,2型糖尿病の罹患率が低い. これは,コレステロール輸送と糖尿病の発症の間の潜在的な関連性を示唆しており,さらなる調査を正当化しています.
科学分野:
- 心血管遺伝学 心血管遺伝学
- メタボリック障害 メタボリック障害
- 分子生物学は分子生物学である.
背景:
- 家族性高コレステロール血症 (FH) はコレステロールの吸収を低下させ,スタチンはコレステロールを増加させ,2型糖尿病 (T2DM) のリスクを高めます.
- 一つの仮説は,膜経コレステロール輸送とT2DMの発症の間のリンクを提示しています.
研究 の 目的:
- T2DMの罹患率とFHの関連性を調査する.
- FH変異型に基づくT2DM流行の変動を調査する.
主な方法:
- オランダでFHのDNA検査を受けた6万3320人の個人を対象とした横断的な研究 (1994年−2014年).
- FH変異の重度による分類:LDL受容体対APOB遺伝子変異,受容体陰性対受容体欠乏性LDL受容体変異.
主要な成果:
- T2DMの罹患率は,FH患者 (1.75%) で,影響を受けていない親戚 (2.93%) (OR, 0.62) と比較して低かった.
- FHにおけるT2DMの調整された罹患率は1.44% (OR,0.49) であった.
- 流行率は,変異型によって異なる:APOB (1.91%) と LDL受容体 (1.33%) と受容体欠乏 (1.44%) と受容体陰性 (1.12%) による.
結論:
- FHの患者は,影響を受けていない親族よりもT2DMの有意に低い罹患率を示した.
- 変異型による観察された変動性は,微妙な関係を示唆しています.
- LDL受容体媒介のコレステロール輸送とT2DMとの間の潜在的な因果関係を確認するために,さらなる長期研究が必要です.
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