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Updated: Apr 16, 2026

Monitoring Leucine-Rich Repeat Containing 8 Channel (LRRC8/VRAC) Activity Using Sensitized-Emission Förster Resonance Energy Transfer (SE-FRET)
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K2Pチャネルゲートメカニズムは,TREK-2の構造とプロザックを含む複合体によって明らかになりました

Yin Yao Dong1, Ashley C W Pike1, Alexandra Mackenzie2

  • 1Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.

Science (New York, N.Y.)
|March 14, 2015
PubMed
まとめ

結晶構造は,TREK-2のカリウムチャネルが,ストレッチや脂肪酸などの刺激に反応するために,どのように形を変えているかを明らかにします. これは,チャネルゲーティングとプロザックの潜在的オフターゲット効果を説明します.

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