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Updated: Apr 15, 2026

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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MAD2L2は,5'-端解剖を阻害することによって,テロメアにおけるDNA修復とDNA破裂を制御する

Vera Boersma1, Nathalie Moatti1, Sandra Segura-Bayona1

  • 1Division of Molecular Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

Nature
|March 25, 2015
PubMed
まとめ

MAD2L2は新しいDNA修復因子で,5'端切除を阻害することでテロメア融合とゲノム不安定性を促進する. その枯渇はテロメアを安定させ,NHEJ経由でDNA二重鎖の断裂修復を防ぐ.

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