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Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Drugs Used in Upper Respiratory Disorders: Overview01:16

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Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
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急性鼻膜炎に対する全身性コルチコステロイド療法

Roderick P Venekamp1, Matthew J Thompson2, Maroeska M Rovers3

  • 1Division Surgical Specialties, Department of Otorhinolaryngology, University Medical Center Utrecht, the Netherlands2Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.

JAMA
|March 25, 2015
PubMed
まとめ
この要約は機械生成です。

重度の急性鼻炎では,抗生物質と併用した経口用コルチコステロイドは,抗生物質のみと比較して短期的な症状緩和を提供することがあります. しかし,経口用コルチコステロイドだけでは,急性鼻炎の結果を改善しません.

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科学分野:

  • 耳鼻喉科 (Otorhinolaryngology) は,耳鼻喉科 (Otorhinolaryngology) を専門とする専門医として,耳鼻喉科 (Otorhinolaryngology) を専門としている.
  • 薬理学 薬理学とは
  • クリニカル・メディシン 臨床医学

背景:

  • 急性鼻炎は,様々な治療法でしばしば管理される一般的な状態です.
  • 急性鼻炎の管理におけるコルチコステロイドの役割は,依然として臨床調査の対象となっている.

研究 の 目的:

  • 経口または親体用コルチコステロイドの有効性を,急性鼻炎に対するプラセボまたはNSAIDと比較して評価する.
  • コルチコステロイドが急性鼻炎患者の臨床結果を改善するかどうかを判断する.

主な方法:

  • ランダム化制御試験の体系的レビューとメタ解析.
  • プラセボまたは非ステロイド性抗炎症薬 (NSAIDs) に対してコルチコステロイド介入の比較.

主要な成果:

  • 抗生物質と併用された経口用コルチコステロイドは,重度の急性鼻炎の短期的な症状緩和に適度な効果を示しました.
  • コルチコステロイド単独治療は,対照群と比較して改善された臨床結果を示さなかった.

結論:

  • 併用療法 (経口用コルチコステロイドと抗生物質) は,重度の急性鼻炎の症状管理に有益である可能性があります.
  • コルチコステロイドは,臨床的に診断された急性鼻炎の単独療法として推奨されません.