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核酸結合オリゴメリゼーションドメイン2受容体は,血小板に発現し,血小板活性化と血栓形成を促進する

Si Zhang1, Shenghui Zhang1, Liang Hu1

  • 1From Key Laboratory of Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, China (Si Zhang, Shenghui Zhang, L.H., L.Z., J.Y., L.C., Z.D.); Department of Internal Medicine, and Institute of Liver Disease, Fudan University Zhongshan Hospital, Shanghai, China (R.X.); Thoracic Oncology Research Laboratory, University of Pennsylvania, Philadelphia, (G.C.); Department of Internal Medicine, University of Kansas School of Medicine, Wichita (J.S.M.); and Department of Physiology and Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA (S.P.K.).

Circulation
|April 1, 2015
PubMed
まとめ

核酸結合オリゴメリゼーションドメイン2 (NOD2) は,血小板に発現し,血小板活性化,血栓形成,炎症,特に感染時の炎症を高める. この研究は,NOD2シグナル伝達と血栓性イベントの間の新しい関連性を明らかにしています.

キーワード:
血小板 (血小板) とはミトゲン活性化タンパク質キナーゼは,ミトゲン活性化タンパク質キナーゼを核酸結合オリゴメリゼーション領域2受容体と相互作用するタンパク質セリン・スレオニンキナーゼ2 2トロンボシス (血栓形成) とは

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