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Updated: Apr 15, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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光学的に活性な1,5-ベンゾチアゼピンに対する簡単な純サイクル添加アプローチ

Yukihiro Fukata1, Keisuke Asano1, Seijiro Matsubara1

  • 1Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyotodaigaku-Katsura, Nishikyo, Kyoto 615-8510, Japan.

Journal of the American Chemical Society
|April 10, 2015
PubMed
まとめ

研究者らは,1,5-ベンゾチアゼピン合成のための新しい,高度にエナチオセレクティブなサイクル添加法を開発しました. この画期的な発見により,薬の発見と疾患の対抗性研究のための光学的に活性な化合物の効率的な生産が可能になりました.

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Cycloaddition Reactions: Overview

Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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