成熟した周辺Bリンパ球における自己耐性の誘導

C C Goodnow¹, J Crosbie, H Jorgensen

¹Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, New South Wales, Australia.

Nature

|November 23, 1989

まとめ

マウスの成熟したB細胞は,受容体結合が値を超えると自己抗原に耐性を持つようになり,IgMの減少につながります. これは,自己反応性B細胞が免疫系で一般的であることを示唆しています.

科学分野:

免疫学免疫学とは
分子生物学は分子生物学である.
自己免疫とは,自己免疫である.

背景:

未成熟および成熟した細胞を含む周辺Bリンパ球は,自己抗原への曝露によって耐性化することができる.
耐性誘導には,自己抗原がB細胞受容体 (BCRs) に結合し,臨界値を上回る必要があります.

研究の目的:

トランス遺伝子マウスのB細胞耐性に関連した分子変化を調査する.
トランスジェニックでないマウスにも同様の耐性メカニズムがあるかどうかを判断する.

主な方法:

B細胞耐性を研究するために,トランスジェニックマウスモデルを使用した.
リンパ性卵泡におけるB細胞抗原受容体発現 (IgMとIgD) を分析した.
トランスジェニックとトランスジェニックでないマウスの受容体発現の比較.

主要な成果:

トランスジェニックマウスの成熟した周辺B細胞は,重要な値を超える自己抗原と遭遇した際に耐性を示した.
耐性B細胞は膜IgMのダウンレギュレーションを示したが,抗原受容体IgDは示さなかった.
同様の抗原受容体発現の変化は,非トランスゲンマウスからの毛細血管B細胞のサブセットで観察されました.

結論:

B細胞における自己抗原誘発の耐性は,IgM発現の減少と関連しています.
非変異遺伝子マウスにおける同様の変化の存在は,クローン的に静止された自己反応性B細胞が,周辺のB細胞レパートリーの一般的な特徴であることを示唆しています.

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