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B-Rafキナーゼの不活性から活性へのダイナミクスに対する,広範に広がった癌を引き起こす突然変異の効果

Kristen A Marino1, Ludovico Sutto1, Francesco Luigi Gervasio1

  • 1Department of Chemistry, University College London, London, U.K.

Journal of the American Chemical Society
|April 14, 2015
PubMed
まとめ

B-RafキナーゼのV600E変異は,活性状態を安定させ,メラノーマ治療戦略にとって極めて重要な活性化ループの柔軟性を高めることによって,その活性性を高めます.

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