関連する実験動画
Updated: Jul 5, 2026

12:16
Robust 3D DNA FISH Using Directly Labeled Probes
Published on: August 15, 2013
35.8K
現代のゲノミクス時代の将来の翻訳的応用:アメリカ心臓協会の科学的声明
Circulation
|April 18, 2015
まとめ
遺伝学とゲノミクスは,心血管疾患と薬物反応の関連性を特定しています. この声明は,より良い予防と治療のために,遺伝的発見と心臓血管の臨床ケアにおけるその適用の間のギャップを埋めます.
科学分野:
- 遺伝学とゲノミクス
- 心血管疾患に関する研究
背景:
- 遺伝学とゲノミクスの最近の進歩は,心血管疾患と薬剤反応の変数に関連した多数の局所を特定しました.
- これらの遺伝学的な発見を,病気の予防と患者のケアのための有意義な臨床応用に翻訳する際には,依然として大きなギャップが残っています.
研究 の 目的:
- 遺伝学的な発見と,心血管疾患の臨床ケアにおけるその実用的な応用の間の翻訳的なギャップを埋めること.
- 基本的な遺伝学的発見を臨床的進歩に変換するための現在のタイムラインを評価する.
主な方法:
- 遺伝子およびゲノム翻訳における過去の成功のレビュー.
- 心血管遺伝学とゲノミクスにおける現在の発見の評価.
- 臨床翻訳のための将来の期待,ツール,能力の評価.
主要な成果:
- 心血管疾患の多くの遺伝的位置を特定した.
- 遺伝的要因の影響を受ける薬剤反応の変数の理解.
- 遺伝学的発見の臨床翻訳の現状と将来の可能性を分析する.
結論:
- 遺伝学的な発見を臨床実践に翻訳する過去の成功を強調する.
- 心血管の健康に関連した現在の遺伝学およびゲノム学上の発見を概説します.
- 遺伝学を通じて心血管疾患の臨床ケアを改善するために必要な将来の期待,ツール,能力の定義.
関連する概念動画
Genomics
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Next-generation Sequencing
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
The Central Dogma
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
Issues And Trends In Healthcare Delivery System
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Pharmacogenomics: Identification of New Drug Targets
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

