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Updated: Apr 14, 2026

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
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タンパク質の構造. 核酸処理酵素における構造-機能関係の直接観察

Matthew J Comstock1, Kevin D Whitley1, Haifeng Jia2

  • 1Department of Physics, Center for the Physics of Living Cells, and Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Science (New York, N.Y.)
|April 18, 2015
PubMed
まとめ

研究者は,タンパク質の構造と機能を直接リンクする新しい単一分子方法を開発しました. この技術は,UvrD DNA修復ヘリケーズにおける2つの異なるDNA解き放たれ活動と構成状態を明らかにしました.

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関連する概念動画

Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
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