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Assessment of Myofilament Ca2+ Sensitivity Underlying Cardiac Excitation-contraction Coupling
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ポリシスティン-1は,L型Ca2+チャネルタンパク質の安定性を支配する心筋細胞メカノセンサです

Zully Pedrozo1, Alfredo Criollo1, Pavan K Battiprolu1

  • 1From Division of Cardiology, Department of Internal Medicine (Z.P., A.C., P.K.B., C.R.M., N.J., X.L., B.A.R., T.G.G., S.L., J.A.H.) and Department of Molecular Biology (B.A.R., J.A.H.), UT Southwestern Medical Center, Dallas, TX; Advanced Center for Chronic Diseases and Centro de Estudios Moleculares de la Célula, Facultad de Medicina & Facultad de Ciencias Químicas y Farmacéuticas, Santiago, Chile (Z.P., A.C.-F., C.F., S.L.); Instituto de Ciencias Biomédicas, Facultad de Medicina (Z.P., S.L.) and Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología (A.C.), Universidad de Chile, Santiago; and Departments of Cellular and Molecular Physiology (M.J.C.), Internal Medicine (S.S.), and Genetics (S.S.), Yale University School of Medicine, New Haven, CT.

Circulation
|April 19, 2015
PubMed
まとめ

ポリシスティン-1 (PC-1) は,心臓のメカノセンサとして作用し,L型カルシウムチャネル活動を調節し,心筋縮を予防します. PC-1は,心臓筋の成長に不可欠な重要なカルシウムチャネルタンパク質を安定させます.

キーワード:
カーディオメガリー (心臓病)メカニカルトランスデュークション,セルラー

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