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Updated: Apr 14, 2026

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
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ゲノムエディティング. 変異性の連鎖反応: 異異同位体の変異を同位体の変異に変換する方法

Valentino M Gantz1, Ethan Bier1

  • 1Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92095, USA. vgantz@ucsd.edu ebier@ucsd.edu.

Science (New York, N.Y.)
|April 25, 2015
PubMed
まとめ

変異性連鎖反応 (MCR) は,CRISPR/Cas9を用いて,同同胞性機能喪失変異を生成する. この技術は,ヘテロジゴス変異をホモジゴス変異に効率的に変換し,多様な生物で広範な応用があります.

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