Th17細胞は,炎症の解消の間に,調節性T細胞に変異する
Nicola Gagliani1, Maria Carolina Amezcua Vesely1, Andrea Iseppon1
1Department of Immunobiology, School of Medicine, Yale University, New Haven, 06520, USA.
Nature
|April 30, 2015
まとめ
炎症性Th17細胞は,抗炎症性調節性T細胞に変換することができる. このトランスディフェリエンテーションは,炎症性疾患の治療のための潜在的な治療戦略を提供します.
科学分野:
- 免疫学 免疫学とは
- 細胞生物学 細胞生物学
- 分子生物学は分子生物学である.
背景:
- Tヘルパー17 (Th17) 細胞は,炎症性疾患に関与しています.
- Th17細胞の可塑性と不安定性は病原性に関連しているが,そのメカニズムは不明である.
- Th17細胞が抗炎症的な役割を果たす可能性は未開拓です.
研究 の 目的:
- 免疫応答中のTh17細胞のインビヴォの転写変化と運命を調査する.
- Th17細胞が他のTヘルパー細胞系統に変異するかどうかを判断する.
- 炎症状態におけるTh17細胞の可塑性の治療の可能性を調査する.
主な方法:
- 新しい運命マッピングマウスモデルを使用して,Th17細胞をex vivoで追跡しました.
- 変換前のおよび後のTh17細胞の転写プロファイリングを行いました.
- Th17細胞変換におけるTGF-βシグナル伝達とアリル炭水化物受容体 (AhR) の役割を分析した.
主要な成果:
- 以前IL-17Aを発現したCD4 (((+)) T細胞が抗炎症フェノタイプを獲得することを実証しました.
- トランスクリプションプロファイルの変化と規制機能の獲得を通じて,規制T細胞のトランスディフェリエンテーションにTh17が確認されました.
- Th17細胞変換における重要な要因として,カノン的なTGF-βシグナル伝達とAhRを特定した.
結論:
- Th17細胞は,調節性T細胞に変異し,炎症解消に貢献することができます.
- Th17細胞の可塑性は,炎症性疾患の潜在的治療標的である.
- Th17細胞の変換を理解することは,免疫ホメオスタシスと疾患の病原性についての洞察を提供します.
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