銅が自然に発生するアルファ-シヌクレインのN-末端アセチル化形態に結合すると,局所螺旋折れが誘発されます

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Updated: Apr 13, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
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Published on: December 16, 2013

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Marco C Miotto, Ariel A Valiente-Gabioud, Giulia Rossetti1

  • 1§Computational Biophysics, German Research School for Simulation Sciences and Computational Biomedicine, Institute for Advanced Simulations IAS-5, Forschungszentrum Jülich, D-52425 Jülich, Germany.

Journal of the American Chemical Society
|May 5, 2015
PubMed
まとめ

アセチル化されたアルファシヌクレイン (AcAS) との脳銅 (Cu(I)) 相互作用は,パーキンソン病 (PD) と関連しています. この研究では,AcAS-Cu(I) 複合体の形成がAcAS構造を安定させ,PDの病原性に影響を与える可能性があることが明らかになりました.

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