トランスクリプションネットワークの理解を深める
Trevor R Sorrells1, Alexander D Johnson1
1Department of Biochemistry & Biophysics and Department of Microbiology & Immunology, Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.
Cell
|May 11, 2015
まとめ
ユカリオット転写ネットワークの共通の特徴は,適応性がない可能性があります. 代わりに,これらの類似性は,より単純な構造を好む,最も抵抗の少ない進化の経路から生じる可能性が高い.
科学分野:
- 進化生物学の進化生物学について
- システム生物学 システム生物学
- ゲノミクスゲノミクスとは
背景:
- ユカリオットのトランスクリプション規制ネットワークは,遺伝子番号,重複接続,機能的冗長性などの保存された特徴を表示します.
- これらの類似性は,しばしば自然選択によって引き起こされる適応として解釈されます.
研究 の 目的:
- 転写規制ネットワークにおける観察された共通点のための代替仮説を提案し,議論する.
- ネットワークの複雑性は,適応的進化の産物に過ぎないという仮定に異議を唱える.
主な方法:
- 遠縁のユカリオットにおける転写制御ネットワークの比較分析.
- 進化の軌跡と最小抵抗の原理の理論的議論.
主要な成果:
- 遺伝子数,接続性,冗長性など,真核生物間の転写ネットワークの驚くべき類似性を特定しました.
- これらの共通の特徴が進化の"最小抵抗"経路の結果であるという仮説を支持する証拠を提示した.
結論:
- 転写ネットワークの構造的な共通点は,直接的な適応ではなく,進化的制約の新興特性であるかもしれない.
- 形成の容易さを好む進化の軌道は,これらの複雑な生物学的ネットワークの保存された特徴を説明することができます.
関連する概念動画
Transcription
36.6K
Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
36.6K
Transcription
160.4K
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
160.4K
Transcription
3.5K
3.5K
Transcription
48.1K
48.1K
Transcription Factors
84.3K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
84.3K
Transcription Factors
27.4K
27.4K


