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Updated: Apr 12, 2026

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
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第3世代のキナーゼ阻害剤によって調節されたワイルドタイプとダブルミュータントEGFRの構造的な違い

Melissa A Lowder1, Amy E Doerner1, Alanna Schepartz1

  • 1Departments of †Chemistry, ‡Molecular Biophysics and Biochemistry, and §Molecular, Cellular, and Developmental Biology, Yale University, 225 Prospect Street, New Haven, Connecticut 06511, United States.

Journal of the American Chemical Society
|May 15, 2015
PubMed
まとめ

肺がんにおける薬剤耐性EGFR変異は,キナーゼ領域の外で異なる構造を持っています. 新しいTKIは正常な構造を回復し,キナーゼ独立性腫瘍学的役割と新しい治療標的を示唆しています.

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