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ヒトのリン酸フルークトキナーゼ-1の構造と,がん関連変異の原子基礎

Bradley A Webb1, Farhad Forouhar2, Fu-En Szu2

  • 1Department of Cell and Tissue Biology, University of California, San Francisco, California 94143, USA.

Nature
|May 19, 2015
PubMed
まとめ

研究者らは,ヒトの血小板リン酸フルークトキナーゼ-1 (PFKP) の最初の結晶構造を決定し,そのテトラマー形成と形状の変化を明らかにした. これらの構造は,がんに関連した変異と,グリコロシスの治療的ターゲティングに関する洞察を提供します.

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