QT

Yuankun Yue1, Monica Castrichini1, Ujala Srivastava1

  • 1From Cardiovascular Research Program, VA New York Harbor Healthcare System, Brooklyn (Y.Y., U.S., F.F., K.S., Z.L., Y.Q., N.E.-S., M.M.H., X.-C.J., M.B.); Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Italy (M.C., P.-L.C., F.L.-P., P.-E.L.); Departments of Medicine, Cell Biology and Pharmacology, State University of New York Downstate Medical Center, Brooklyn (U.S., F.F., Z.L., Y.Q., M.M.H., X.-C.J., M.B.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland (Z.Z.); Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison (C.J.); Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York (E.A.S.); Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institute, Stockholm, Sweden (M.W.-H.); Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Laval University, Quebec City, Canada (M.C.); and Department of Medicine, New York University School of Medicine, New York (M.B.).

Circulation
|May 22, 2015
PubMed
まとめ

自身免疫疾患からのAnti-Ro抗体は,HERGチャネルを標的とし,IKrを阻害し,QTc延長を引き起こします. この研究は,病原性の関連性を確立し,罹患した患者に定期的なECGスクリーニングを行うことを提案しています.

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