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Genome Annotation and Assembly03:36

Genome Annotation and Assembly

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Synthetic Biology02:55

Synthetic Biology

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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
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Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Genetic Screens02:46

Genetic Screens

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

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Updated: Apr 12, 2026

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms
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Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms

Published on: May 9, 2017

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ゲノムスケールモデルを使用して,生物学的能力を予測する.

Edward J O'Brien1, Jonathan M Monk2, Bernhard O Palsson3

  • 1Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA; Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA 92093, USA.

Cell
|May 23, 2015
PubMed
まとめ
この要約は機械生成です。

制約ベースの再構築と分析 (COBRA) 方法は,細胞機能と遺伝子ノックアウト効果を予測します. これらのゲノムスケールのモデルは,代謝工学と進化の研究に価値があります.

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In Vivo Modeling of the Morbid Human Genome using Danio rerio
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In Vivo Modeling of the Morbid Human Genome using Danio rerio

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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

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関連する実験動画

Last Updated: Apr 12, 2026

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In Vivo Modeling of the Morbid Human Genome using Danio rerio
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In Vivo Modeling of the Morbid Human Genome using Danio rerio

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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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科学分野:

  • システム生物学 システム生物学
  • メタボリックエンジニアリング
  • ゲノミクスゲノミクスとは

背景:

  • 制約に基づく再構築と分析 (COBRA) の方法は,1990年代半ばから大幅に進化しました.
  • ゲノムスケールのモデルは,細胞機能を予測する能力がますます高まっています.

研究 の 目的:

  • 制約に基づく再構築と分析 (COBRA) 方法について読者に紹介する.
  • 様々な科学分野におけるCOBRAの応用を強調する.

主な方法:

  • ゲノムスケールモデルの開発.
  • COBRAを使用して,細胞のフェノタイプを予測する.
  • 遺伝子改変の影響を分析する.

主要な成果:

  • COBRAの方法は,異なる基板の細胞成長を正確に予測することができます.
  • これらの方法は,遺伝子ノックアウトの結果を効果的に予測します.
  • 細胞機能の範囲を予測する有用性が実証されています.

結論:

  • COBRAの方法は,細胞の代謝と機能を理解するための強力なツールを提供します.
  • アプリケーションは,代謝工学,抗生物質設計,進化生物学を網羅しています.
  • このプライマーは,これらの影響力のあるテクニックへの入門として役立つ.