Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

21.8K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
21.8K
Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

3.0K
3.0K
Imperfections in Crystal Structure: Point, Line and Plane Defects01:25

Imperfections in Crystal Structure: Point, Line and Plane Defects

110
A perfect crystal, in theory, has a uniform structure with the same unit cell and lattice points throughout. However, any deviation from this periodic arrangement is known as an imperfection or defect. These defects can be categorized into three types: point, line, and plane defects.Point defects occur when there is a deviation from the ideal due to missing atoms, displaced atoms, or additional atoms. These imperfections might occur due to imperfect packing during crystallization or because of...
110
Imperfections in Crystal Structure: Non-Stoichiometric Defects01:29

Imperfections in Crystal Structure: Non-Stoichiometric Defects

94
Non-stoichiometric defects refer to a type of defect in the crystal structure of a compound where the ratio of its constituent elements deviates from the ideal stoichiometric ratio. There are two main types of non-stoichiometric defects: metal excess defects and metal deficiency defects.Metal excess defects occur when there is a slight surplus of metal ions than what is required by the stoichiometric ratio of the compound. For example, heating a sodium chloride crystal in sodium vapor results...
94
Imperfections in Crystal Structure: Stoichiometric Point Defects01:26

Imperfections in Crystal Structure: Stoichiometric Point Defects

93
Schottky defects arise when some lattice points in a crystal, such as those in NaCl, remain unoccupied, creating lattice vacancies without disturbing the overall electrical neutrality of the crystal. This defect is common in ionic crystals where the positive and negative ions are similar in size, as seen in sodium chloride and cesium chloride. The presence of Schottky defects enables the crystal to conduct electricity to a small extent through an ionic mechanism. Electric fields cause nearby...
93
Amyloid Fibrils03:03

Amyloid Fibrils

13.1K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
13.1K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

The complexome contextualizes proteomics data to fingerprint biological states and highlight perturbed functional modules in disease.

NPJ systems biology and applications·2026
Same author

Toward a unified framework for determining conformational ensembles of disordered proteins.

Nature methods·2026
Same author

Multi-omics analysis reveals ER stress as a main feature in two endothelial cell models of N-linked congenital disorders of glycosylation.

Molecular genetics and metabolism·2026
Same author

Expression, purification, and biophysical characterization of liquid-liquid phase separation of full-length hnRNPA2B1.

Protein expression and purification·2025
Same author

DisProt in 2026: enhancing intrinsically disordered proteins accessibility, deposition, and annotation.

Nucleic acids research·2025
Same author

Phase-separating fusion proteins drive cancer by upsetting transcription regulation.

Genome biology·2025
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Same journal

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Cell·2026
関連記事をすべて見る

関連する実験動画

Updated: Apr 12, 2026

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
09:25

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments

Published on: November 1, 2024

3.0K

スナップショット:内在的な構造障害

Mainak Guharoy1, Kris Pauwels1, Peter Tompa2

  • 1VIB Structural Biology Research Center (SBRC), Vlaams Instituut voor Biotechnologie, 1050 Brussel, Belgium; Structural Biology Brussels (SBB), Vrije Universiteit Brussel, 1050 Brussel, Belgium.

Cell
|May 23, 2015
PubMed
まとめ
この要約は機械生成です。

本質的に無秩序なタンパク質 (IDP) と領域 (IDR) は,その自然かつ機能的状態である固定された3D構造を欠いている. これらのダイナミックな分子は展開されず,無性化されず,生物学的な役割のための固有の構造的柔軟性を持っています.

さらに関連する動画

Author Spotlight: Unlocking the World of Intrinsically Disordered Regions with Cellular Sensing and Responses
05:13

Author Spotlight: Unlocking the World of Intrinsically Disordered Regions with Cellular Sensing and Responses

Published on: January 12, 2024

1.6K
Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins
07:24

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins

Published on: September 23, 2021

2.4K

関連する実験動画

Last Updated: Apr 12, 2026

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
09:25

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments

Published on: November 1, 2024

3.0K
Author Spotlight: Unlocking the World of Intrinsically Disordered Regions with Cellular Sensing and Responses
05:13

Author Spotlight: Unlocking the World of Intrinsically Disordered Regions with Cellular Sensing and Responses

Published on: January 12, 2024

1.6K
Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins
07:24

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins

Published on: September 23, 2021

2.4K

科学分野:

  • バイオケミストリー バイオケミストリー
  • 分子生物学は分子生物学である.
  • 構造生物学 構造生物学とは

背景:

  • 固有無秩序タンパク質 (IDP) または特定のタンパク質セグメント,固有無秩序領域 (IDR) と呼ばれる多くのタンパク質は,通常の生理学的条件下で安定した3次元構造を採用しません.
  • 定義された構造がないにもかかわらず,これらのタンパク質は変性化または誤折り合いをしていないと考えられています.

研究 の 目的:

  • 本質的に無秩序なタンパク質と領域の性質を明らかにする.
  • 本質的な構造障害は,これらのタンパク質のネイティブおよび機能的状態を表していることを明確にするために.

主な方法:

  • タンパク質構造データの分析.
  • タンパク質の折りたたみとダイナミクスに関する既存の文献のレビュー.
  • 生物物理的特徴付け技術 (暗示).

主要な成果:

  • IDPとIDRは高度な柔軟性とダイナミクスを発揮します.
  • 安定した構造の欠如は固有の特徴であり,デナチュレーションではありません.
  • この障害は,その生物学的機能に極めて重要です.

結論:

  • 内在的な構造障害は,重要な種類のタンパク質の固有で機能的な状態である.
  • IDPとIDRを理解することは,タンパク質の機能と生物学的プロセスを理解するために不可欠です.