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Updated: Apr 12, 2026

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
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Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

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安定した変異性p53に対する腫瘍依存を治療のために利用することによって生存率を改善する

E M Alexandrova1, A R Yallowitz1, D Li1

  • 1Department of Pathology, Stony Brook University, Stony Brook, New York 11794, USA.

Nature
|May 27, 2015
PubMed
まとめ

ミッセンスの変異性p53 (mutp53) タンパク質は,がんの進行と化学抵抗を駆動する. HSP90/HDAC6によって安定したmutp53をターゲットにすることで,腫瘍の成長を効果的に減少させ,臨床前のモデルで生存期間を延長します.

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