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関連する概念動画

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

7.0K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
9.3K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

4.3K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

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Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
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関連する実験動画

Updated: Apr 11, 2026

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
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サブクリニックの甲状腺機能障害と骨折リスク:メタ解析

Manuel R Blum1, Douglas C Bauer2, Tinh-Hai Collet3

  • 1Department of General Internal Medicine, Inselspital, Bern University Hospital, Bern, Switzerland.

JAMA
|May 27, 2015
PubMed
まとめ

甲状腺機能低下症ではなく,亜臨床的甲状腺機能過剰症は,骨折のリスク,特に股関節骨折を増加させます. 低甲状腺刺激ホルモン (TSH) レベルは,より高い骨折率と相関しており,治療の有効性に関するさらなる調査を正当化しています.

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科学分野:

  • エンドクリノロジー エンドクリノロジー
  • 骨の健康 骨の健康とは
  • エピデミオロジー エピデミオロジー

背景:

  • 副臨床的な甲状腺機能障害と骨折の関連性は十分に確立されていません.
  • この関連性を調査する臨床試験は欠けている.

研究 の 目的:

  • サブクリニックの甲状腺機能不全と骨折との関連を判断する.
  • 具体的には,股関節,非脊椎,脊椎,およびすべての骨折タイプを検査します.

主な方法:

  • 将来のコホート研究の体系的なレビューとメタ解析.
  • 13コホート (70,298人の参加者) のデータを分析した.
  • 甲状腺機能は,TSHレベルに基づいて,ユーチロイド症,サブクリニック性甲状腺機能低下症,サブクリニック性甲状腺機能低下症に分類されます.

主要な成果:

  • サブクリニック性甲状腺症は,股関節骨折のリスク (HR 1.36) と骨折リスク (HR 1.28) の増加と関連していました.
  • 非常に低いTSHレベル (<0.10 mIU/L) は,ヒップ,任意の骨折,脊椎骨折のリスクが著しく高かったことを示しました.
  • サブ臨床的甲状腺機能低下症と骨折のリスクとの間に有意な関連性は見つかりませんでした.

結論:

  • サブクリニック性甲状腺機能過剰症は,骨折,特に股関節骨折のリスクが高いことと関連しています.
  • このリスクは,TSHレベルが低い場合や,内生性サブクリニック性甲状腺機能過剰症においてより顕著である.
  • サブクリニック性甲状腺機能過剰症の治療が骨折リスクを軽減できるかどうかを調べるためにさらなる研究が必要です.