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Updated: Apr 11, 2026

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
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量子力学/分子力学計算反応ネットワークは,シトクロームP450カムとその変異体T252Aが酸化経路をどのように選択するかを明らかにしています

Binju Wang1, Chunsen Li2,3, Kshatresh Dutta Dubey1

  • 1†Institute of Chemistry and The Lise Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel.

Journal of the American Chemical Society
|May 27, 2015
PubMed
まとめ

量子力学/分子力学的計算により,P450酵素における新しい触媒経路が明らかになり",第2酸化物質"は排除され,T252A変異体による基板特異性エポキシデーションが説明される.

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