目標指向の空間ナビゲーションのためのプレフロントル・タラモ・ヒポカンプス回路
Hiroshi T Ito1, Sheng-Jia Zhang1, Menno P Witter1
1Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres gate 9, MTFS, 7491 Trondheim, Norway.
Nature
|May 29, 2015
まとめ
核再結成を含む前頭前タラミック回路は,海馬がナビゲーション軌道を表現するために不可欠です. この経路は,脳が目標指向のナビゲーションで将来の経路をマッピングすることを可能にします.
科学分野:
- 神経科学は神経科学である.
- 認知神経科学とは
- システム神経科学 システム神経科学
背景:
- 空間ナビゲーションは,現在の位置と将来の位置を理解することに依存しています.
- 海馬の神経細胞は位置と経路の軌道をコードしますが,ゴール方向情報の起源は不明です.
研究 の 目的:
- ナビゲーション中に海馬の軌道を表現する神経回路を特定する.
- 目標指向の空間的行動におけるプレフロントル・タラミック経路の役割を明らかにする.
主な方法:
- ネズミの電気生理学的記録は,ニューロンの発火パターンを観察するためのものです.
- 特定の神経経経路を妨害するために,病変と光遺伝的静音化技術.
- 中部前頭前皮質,核再会,そして海馬における軌道の依存的な発射の分析.
主要な成果:
- 軌道を依存するニューロンの発火は,中央前頭前皮質,核再会,CA1海馬で特定されました.
- 核再結成の障害は,CA1領域における軌道を依存する発射を著しく低下させた.
- 核再結成の入力がないCA3海馬領域は,軌道に依存する活動が最小限に示された.
結論:
- 中間前頭前皮質から核再結成までの投影は,ナビゲーションにおける将来の経路を表現するために重要である.
- タラムスは,特に核再会は,ナビゲーションのための皮質のコミュニケーションの重要なリレーとして機能します.
- この前頭前頭前頭皮と海馬の回路は,目標指向の空間ナビゲーションに不可欠です.
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