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Author Spotlight: RNAi Inheritance and ChIP in C. elegans
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ゲノムシューエンシング. HUSH複合体のエピジェネティックサイレンシングは,ヒト細胞における位置効果の変化を媒介する

Iva A Tchasovnikarova1, Richard T Timms1, Nicholas J Matheson1

  • 1Department of Medicine, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0XY, UK.

Science (New York, N.Y.)
|May 30, 2015
PubMed
まとめ

前進的な遺伝子スクリーンは,表遺伝的抑圧に不可欠なヒトサイレンスハブ (HUSH) 複合体を特定しました. HUSHの喪失は,H3K9me3を減少させ,ヘテロクロマチンと遺伝子サイレンシングに影響を与えます.

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