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関連する概念動画

Anatomy of the Brain: Major Regions01:20

Anatomy of the Brain: Major Regions

13.3K
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
13.3K
Cerebrum: Anatomical Overview I01:26

Cerebrum: Anatomical Overview I

6.8K
The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...
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Organization of the Brain01:30

Organization of the Brain

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The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
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Anatomy of the Brain: Ventricles01:18

Anatomy of the Brain: Ventricles

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There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen.
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Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

6.1K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
6.1K
Overview of Anatomy and Physiology01:24

Overview of Anatomy and Physiology

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Human anatomy is the scientific study of the body's structures. Some of these structures are very small and can only be observed and analyzed with the assistance of a microscope. Other larger structures can readily be seen, manipulated, measured, and weighed. The word "anatomy" comes from a Greek root that means "to cut apart." Human anatomy was first studied by observing the body's exterior and the wounds of soldiers and other injuries. Later, physicians were allowed to...
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Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
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人間のマイクロプロセッサの機能的解剖学

Tuan Anh Nguyen1, Myung Hyun Jo2, Yeon-Gil Choi1

  • 1Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea; School of Biological Sciences, Seoul National University, Seoul 151-742, Korea.

Cell
|June 2, 2015
PubMed
まとめ
この要約は機械生成です。

DROSHAとDGCR8を含むマイクロプロセッサは,プリミRNAを正確に処理する. この複合体は,特定のRNAモチーフを認識し,臨界距離を測定することによって,正しいマイクロRNA (miRNA) の成熟を保証します.

さらに関連する動画

Exploring Deep Space - Uncovering the Anatomy of Periventricular Structures to Reveal the Lateral Ventricles of the Human Brain
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A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
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Exploring Deep Space - Uncovering the Anatomy of Periventricular Structures to Reveal the Lateral Ventricles of the Human Brain
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A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
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科学分野:

  • 分子生物学は分子生物学である.
  • RNA 生物学 RNA 生物学
  • バイオケミストリー バイオケミストリー

背景:

  • マイクロRNA (miRNA) の成熟は,遺伝子調節のための重要なプロセスです.
  • RNase III DROSHAとその共因子DGCR8を含むマイクロプロセッサ複合体は,miRNAの成熟を開始する.
  • マイクロプロセッサによる pri-miRNA 認識の正確なメカニズムを理解することは,miRNA 生成を理解するために不可欠です.

研究 の 目的:

  • 人間のマイクロプロセッサ複合体がプライミRNAを認識する構造的・機能的メカニズムを解明する.
  • マイクロプロセッサ複合体のステキオメトリーと最小の機能的なコンポーネントを決定する.
  • プリミRNA処理に関わる特定の認識要素と相互作用を特定する.

主な方法:

  • 精製された再結合ドロシャとDGCR8タンパク質を用いたヒトマイクロプロセッサ複合体の再構成.
  • 複雑なステキオメトリーを決定し,最小限の機能的なコアを特定するための生化学的分析.
  • タンパク質-RNAの相互作用の分析と,プリミRNAの特定の認識モチーフの特定.

主要な成果:

  • 人間のマイクロプロセッサは,約364 kDaのヘトロトリメリック複合体で,1つのDROSHAと2つのDGCR8分子で構成されています.
  • 最小限の機能的なコアは,DROSHAとDGCR8からの23アミノ酸ペプチドで構成されています.
  • DROSHAは基底ssRNA-dsRNA結合から11bpを測定し,リールとして機能し,DGCR8は幹と頂点要素を結合する.
  • DROSHAとDGCR8による基礎UGとアピカルUGのモチーフの特定認識は,適切な複雑な方向性と正確な処理を保証します.

結論:

  • この研究は,マイクロプロセッサ複合体によるプリミRNA処理のメカニズムを明らかにし,以前の論争を解決しました.
  • プリミRNA処理の詳細なモデルが提案され,基板認識と分裂におけるDROSHAとDGCR8の役割を強調しています.
  • これらの発見は,miRNA生体生成の調節とその細胞機能への影響について,根本的な洞察を提供します.