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Updated: Apr 11, 2026

Time-resolved Förster Resonance Energy Transfer Assays for Measurement of Endogenous Phosphorylated STAT Proteins in Human Cells
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JAK-STAT信号伝達のキナーゼ独立小分子阻害

Danny Hung-Chieh Chou1, Amedeo Vetere, Amit Choudhary2

  • 1‡Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.

Journal of the American Chemical Society
|June 5, 2015
PubMed
まとめ

小分子BRD0476は,USP9X経由でJAK-STAT経路を抑制することによって,臓細胞を保護する. これは,USP9Xが炎症を調節する新しい標的であることを明らかにします.

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